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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52261: 3-ketoacyl-CoA thiolase A, peroxisomal

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acetyl-CoA C-acyltransferase. [EC: 2.3.1.16]
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
    		 194 A0A024R2M6 A0A024R2M6 A0A060T969 A0A060T969 A0A074TA90 A0A074TA90 A0A075AQX7 A0A075AQX7 A0A086KXI0 A0A086KXI0
    (184 more...)
    Acetyl-CoA C-acetyltransferase. [EC: 2.3.1.9]
    2 acetyl-CoA = CoA + acetoacetyl-CoA.
      		 12 A0A0F7UGB5 A0A0F7UGB5 A0A0J5PHV1 A0A0J5PHV1 B0Y6S9 B0Y6S9 E3TEF2 E3TEF2 F0VIP9 F0VIP9
      (2 more...)
      Dodecenoyl-CoA isomerase. [EC: 5.3.3.8]
      (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.
      • Also catalyzes the interconversion of 3-acetylenic fatty acyl thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty acid chain lengths C(6) to C(12).
      		 2 M2XB90 M2XB90
      3-hydroxybutyryl-CoA epimerase. [EC: 5.1.2.3]
      (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.
        		 2 M2XB90 M2XB90
        3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.35]
        (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
        • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
        • Some enzymes act, more slowly, with NADP(+).
        • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
        		 2 M2XB90 M2XB90
        Enoyl-CoA hydratase. [EC: 4.2.1.17]
        (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
        • Acts in the reverse direction.
        • With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
        		 2 M2XB90 M2XB90