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CATH Superfamily 3.40.430.10

Dihydrofolate Reductase, subunit A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Dihydrofolate Reductase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6554: Riboflavin biosynthesis protein RibD

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diaminohydroxyphosphoribosylaminopyrimidine deaminase. [EC: 3.5.4.26]
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3).
  • The substrate is the product of EC 3.5.4.25.
 328 A0A069XUQ4 A0A069XUQ4 A0A069ZSI1 A0A069ZSI1 A0A070DM52 A0A070DM52 A0A070V6B6 A0A070V6B6 A0A074IPE1 A0A074IPE1
(318 more...)
5-amino-6-(5-phosphoribosylamino)uracil reductase. [EC: 1.1.1.193]
5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6- (5-phospho-D-ribosylamino)uracil + NADPH.
    		 310 A0A069XUQ4 A0A069XUQ4 A0A069ZSI1 A0A069ZSI1 A0A070DM52 A0A070DM52 A0A070V6B6 A0A070V6B6 A0A074IPE1 A0A074IPE1
    (300 more...)
    2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase. [EC: 1.1.1.302]
    2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)(+) = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.
    • The reaction proceeds in the opposite direction.
    • A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant.
    • Differs from EC 1.1.1.193 since it does not catalyze the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate.
    		 20 A0A075WGS4 A0A075WGS4 A0A101DEA8 A0A101DEA8 A0A166BU68 A0A166BU68 A0A166CW90 A0A166CW90 A0A1D3L098 A0A1D3L098
    (10 more...)