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CATH Superfamily 3.40.390.10

Collagenase (Catalytic Domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4169: Fragilysin

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fragilysin. [EC: 3.4.24.74]
Broad proteolytic specificity, bonds hydrolyzed includes -Gly-|-Leu-, -Met-|-Leu-, -Phe-|-Leu-, -Cys-|-Leu-, -Leu-|-Gly-.
  • Thought to be a cause of diarrhea.
  • Hydrolyzes extracellular matrix proteins, and disrupts tight junctions of intstinal cells.
  • Also degrades intracellular, cytoskeletal proteins actin, myosin and others.
  • Belongs to peptidase family M10.
 20 A0A015QRK4 A0A015QRK4 A0A015WDV4 A0A015WDV4 A0A015X6J6 A0A015X6J6 A0A016BQI8 A0A016BQI8 A0A016BR69 A0A016BR69
(10 more...)