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CATH Superfamily 3.40.390.10

Collagenase (Catalytic Domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13268: Snake venom metalloproteinase BaP1

There are 13 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trimerelysin I. [EC: 3.4.24.52]
Cleavage of only two bonds: 10-His-|-Leu-11 and 14-Ala-|-Leu-15, in the insulin B chain.
  • Hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis).
  • Belongs to peptidase family M12B.
 3 B7P4M8 E0VJV8 E0W1A6
Trimerelysin II. [EC: 3.4.24.53]
Cleavage of 3-Asn-|-Gln-4, 10-His-|-Leu-11 and 14-Ala-|-Leu-15 in the insulin B chain, and the bond Z-Gly-Pro-|-Leu-Gly-Pro in a small molecule substrate of microbial collagenase.
  • Nonhemorrhagic endopeptidase from the venom of the habu snake (Trimeresurus flavoviridis).
  • Belongs to peptidase family M12B.
 3 P14530 P20165 U3KRG1
Atrolysin C. [EC: 3.4.24.42]
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1.
  • Hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Exist as two forms, c and d.
  • Digests type IV collagen.
  • Phosphoramidon inhibits in the 0.1 mM range.
  • Hemorrhagic toxin-2 of C.ruber ruber has the same molecular weight and specificity.
  • Belongs to peptidase family M12B.
 2 P15167 Q90392
Russellysin. [EC: 3.4.24.58]
Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of Arg-|-Xaa bonds. Has no action on insulin B chain.
  • Belongs to peptidase family M12B.
 2 Q7LZ61 Q7T046
Fibrolase. [EC: 3.4.24.72]
Hydrolysis of 14-Ala-|-Leu-15 in insulin B chain and 413-Lys-|-Leu-414 in alpha-chain of fibrinogen.
  • Belongs to peptidase family M12.
 2 P28891 P83255
Adamalysin. [EC: 3.4.24.46]
Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15-Leu-|-Tyr- 16, and 16-Tyr-|-Leu-17 of insulin B chain.
  • From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus).
  • Two isoenzymes of approximately 24 kDa that inactivate alpha-1- proteinase inhibitor by a single cleavage.
  • Belongs to peptidase family M12B.
 2 P34179 Q7LZP2
Atrolysin E. [EC: 3.4.24.44]
Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in A chain. Cleaves type IV collagen at 73-Ala-|-Gln-74 in alpha-1-(IV) and at 7-Gly-|-Leu-8 in alpha-2-(IV).
  • Hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Digests basement membrane components, including the triple helix of type IV collagen.
  • Such action is believed to contribute to the hemorrhagic property by weakening capillary walls.
  • Belongs to peptidase family M12B.
 2 P34182 Q92119
Ruberlysin. [EC: 3.4.24.48]
Cleavage of 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 bonds of the B chain of insulin; His-|-Pro, Pro-|-Phe, and Trp-|-Ser of angiotensin I; and Gly-|-Phe of Met enkephalin.
  • Hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber).
  • Cleaves fibrinogen.
  • Belongs to peptidase family M12B.
 1 P20897
Atroxase. [EC: 3.4.24.43]
Cleavage of 5-His-|-Leu-6, 9-Ser-|-His-10, 10-His-|-Leu-11, 14-Ala-|-Leu- 15 and 16-Tyr-|-Leu-17 in insulin B chain.
  • A nonhemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Cleaves fibrinogen.
  • Belongs to peptidase family M12B.
 1 Q91401
Bothropasin. [EC: 3.4.24.49]
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 in insulin B chain.
  • Caseinolytic endopeptidase of jararaca snake (Bothrops jararaca) venom.
  • Belongs to peptidase family M12B.
 1 O93523
Atrolysin A. [EC: 3.4.24.1]
Cleavage of 3-Asn-|-Gln-4, 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu- 15 and 16-Tyr-|-Leu-17 in insulin B chain; removes C-terminal Leu from small peptides.
  • A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of the western diamondback rattlesnake.
  • The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity.
  • Belongs to peptidase family M12B.
 1 Q92043
Jararhagin. [EC: 3.4.24.73]
Cleavage of 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 bonds in insulin B chain.
  • Hemorrhagic endopeptidase from the venom of the jararaca snake.
  • Belongs to peptidase family M12.
 1 P30431
Atrolysin B. [EC: 3.4.24.41]
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves Xaa-|-Ser bonds in glucagon.
  • From the venom of the western diamondback rattlesnake (Crotalus atrox).
  • Belongs to peptidase family M12B.
 1 Q90391