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CATH Superfamily 3.40.390.10

Collagenase (Catalytic Domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Collagenase (Catalytic Domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13247: Matrix metalloproteinase 14 (Membrane-inserted)

There are 11 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Gelatinase A. [EC: 3.4.24.24]
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
  • Belongs to peptidase family M10B.
 48 A0A024R6R4 A0A024R6R4 A0A0B2NVP2 A0A0B2NVP2 A0A0B2PNA1 A0A0B2PNA1 A0A0B2Q519 A0A0B2Q519 A0A0B2Q524 A0A0B2Q524
(38 more...)
Interstitial collagenase. [EC: 3.4.24.7]
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
  • The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain.
  • Alpha-macroglobulins are cleaved much more rapidly.
  • The enzyme is widely distributed in vertebrate animals.
  • Belongs to peptidase family M10B.
 32 A0A061I979 A0A061I979 B7PMT8 B7PMT8 B9RD50 B9RD50 B9RUG6 B9RUG6 B9RUG7 B9RUG7
(22 more...)
Gelatinase B. [EC: 3.4.24.35]
Cleavage of gelatin types I and V and collagen types IV and V.
  • Belongs to peptidase family M10B.
 20 A0A059PAA7 A0A059PAA7 B3F2X1 B3F2X1 O18733 O18733 P14780 P14780 P41245 P41245
(10 more...)
Membrane-type matrix metalloproteinase-1. [EC: 3.4.24.80]
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
  • Believed to play an important role in the activation of progelatinase A at cell surfaces.
  • Belongs to peptidase family M10.
 16 E0VM71 E0VM71 P50281 P50281 P53690 P53690 Q10739 Q10739 Q5RES1 Q5RES1
(6 more...)
Stromelysin 1. [EC: 3.4.24.17]
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
  • Extracellular endopeptidase of vertebrate tissues.
  • Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase.
  • Belongs to peptidase family M10B.
 12 P03957 P03957 P08254 P08254 P28862 P28862 P28863 P28863 Q28397 Q28397
(2 more...)
Macrophage elastase. [EC: 3.4.24.65]
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
  • Belongs to peptidase family M10B.
 10 G3GUV3 G3GUV3 P34960 P34960 P39900 P39900 P79227 P79227 Q63341 Q63341
Stromelysin 2. [EC: 3.4.24.22]
Similar to stromelysin 1, but action on collagen types III, IV and V is weak.
  • Digests gelatin types I, III, IV, V, fibronectin and proteoglycan.
  • Belongs to peptidase family M10B.
 10 A0A061I711 A0A061I711 A1L3D0 A1L3D0 O55123 O55123 P07152 P07152 P09238 P09238
Matrilysin. [EC: 3.4.24.23]
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
  • Similar in specificity to stromelysin, but more active on azocoll.
  • Belongs to peptidase family M10B.
 8 P09237 P09237 P50280 P50280 P55032 P55032 Q10738 Q10738
Envelysin. [EC: 3.4.24.12]
Hydrolysis of proteins of the fertilization envelope and dimethylcasein.
  • Dissolves fertilization envelope in embryos of sea urchin.
  • Belongs to peptidase family M10B.
 6 P22757 P22757 P91953 P91953 Q70AB1 Q70AB1
Neutrophil collagenase. [EC: 3.4.24.34]
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
  • Similar to interstitial collagenase in specificity.
  • Stored in the specific granules of neutrophil leukocytes.
  • Belongs to peptidase family M10B.
 6 O70138 O70138 O88766 O88766 P22894 P22894
Endo-1,4-beta-xylanase. [EC: 3.2.1.8]
Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
    		 2 A0A0H5CVK8 A0A0H5CVK8
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