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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7532: Aldehyde dehydrogenase family protein

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aldehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.5]
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
    		 149 A0A017IIS8 A0A027TS68 A0A028ABY6 A0A029KX88 A0A029LQM4 A0A029PPQ7 A0A037YAA6 A0A060V515 A0A062Y1R3 A0A069XLJ5
    (139 more...)
    Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
    An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
    • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
    • Formerly EC 1.1.1.70.
    		 77 A0A027TS68 A0A028ABY6 A0A029KX88 A0A037YAA6 A0A060V515 A0A069XLJ5 A0A0A0F890 A0A0A8KF27 A0A0A8U783 A0A0B7G8U3
    (67 more...)
    Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]
    4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH.
    • The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates.
    • The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54).
    • As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate.
    • Formerly EC 1.5.1.35.
    		 8 A0A024KUT4 A0A1J8P315 A7ZLC8 B3X393 C9Y2T2 F3V216 F3WHJ6 F5N223
    Transferred entry: 1.2.5.2. [EC: 1.2.99.3]
      		1 C9Y2T2
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