View in Gene3D

CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 17557: Delta-1-Pyrroline-5-carboxylate dehydrogenase 1, i...

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-glutamate gamma-semialdehyde dehydrogenase. [EC: 1.2.1.88]
L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH.
  • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
  • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
  • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
  • NADP(+) can also act as acceptor, but with lower activity.
  • Formerly EC 1.5.1.12.
 1245 A0A011AI52 A0A023CRX5 A0A023DF63 A0A023P0I1 A0A024P563 A0A024Q8D6 A0A024Q9I9 A0A024RAD8 A0A031IGH2 A0A033UMI5
(1235 more...)
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)). [EC: 1.2.1.9]
D-glyceraldehyde 3-phosphate + NADP(+) + H(2)O = 3-phospho-D-glycerate + NADPH.
    		 103 A0A023P0I1 A0A063XE08 A0A0B5NF19 A0A0B5RAU9 A0A0B5U483 A0A0D0GHG8 A0A0E0VTC3 A0A0E8T7M0 A0A0F5RIL4 A0A0F6FPH5
    (93 more...)
    Transferred entry: 1.2.1.88. [EC: 1.5.1.12]
      		84 A0A045IY86 A0A069RYV3 A0A073I1Q5 A0A076P0Y3 A0A078TDV9 A0A083WCI0 A0A0A0XDK5 A0A0G4DXU0 A0A0H3M3D0 A0A0H3P2Y7
      (74 more...)
      Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]
      Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
      • In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine.
      • This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria.
      • In contrast, different enzymes are involved in the first reaction.
      • In plants, this reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC 1.1.99.1 or soluble EC 1.1.3.17.
      • In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.
      		 4 A0A1N4DDV3 A0A1N4WYT9 A0A1N6C9K7 Q4A0E7
      Pyrroline-5-carboxylate reductase. [EC: 1.5.1.2]
      L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
      • Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.
      		 2 A2QNB0 G3XYQ8
      Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
      An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
      • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
      • Formerly EC 1.1.1.70.
      		 1 A3LNR1