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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17524: Succinate-semialdehyde dehydrogenase [NADP(+)] 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]
Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.
    		 277 A0A017IGD3 A0A023YX47 A0A024L3N1 A0A025BR59 A0A026V4G8 A0A027ZRI5 A0A028E097 A0A029I192 A0A029IUQ8 A0A029KW10
    (267 more...)
    Succinate-semialdehyde dehydrogenase (NAD(+)). [EC: 1.2.1.24]
    Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.
    • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
    • It is similar to EC 1.2.1.79 and EC 1.2.1.16 but is specific for NAD(+).
    		 97 A0A023YX47 A0A024L3N1 A0A025BR59 A0A026V4G8 A0A027ZRI5 A0A028E097 A0A066QBP8 A0A069XL49 A0A070FH78 A0A070SNM2
    (87 more...)
    Succinate-semialdehyde dehydrogenase (NADP(+)). [EC: 1.2.1.79]
    Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
    • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
    • It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+).
    • The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
    		 74 A0A049DLQ0 A0A089QNK5 A0A0C7DC15 A0A0E2W6E6 A0A0E2WGC2 A0A0E2WYM6 A0A0E8WS10 A0A0G4DWF5 A0A0H3L4Y9 A0A0H3MSE4
    (64 more...)
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