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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17520: Methylmalonate-semialdehyde dehydrogenase [acylati...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylmalonate-semialdehyde dehydrogenase (CoA acylating). [EC: 1.2.1.27]
2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH.
  • Also converts 3-oxopropanoate into acetyl-CoA.
  • The reaction occurs in two steps with the decarboxylation process preceding CoA-binding.
  • Bicarbonate rather than CO(2) is released as a final product.
 1656 A0A009G4U0 A0A009GEQ9 A0A009I3N0 A0A009I8K5 A0A009K3P9 A0A009KVU4 A0A009LKC7 A0A009MXH8 A0A009R3H1 A0A009S6U7
(1646 more...)
Malonate-semialdehyde dehydrogenase (acetylating). [EC: 1.2.1.18]
3-oxopropanoate + CoA + NAD(P)(+) = acetyl-CoA + CO(2) + NAD(P)H.
    		 1007 A0A015M4E6 A0A023CP03 A0A023CQ20 A0A023CRF8 A0A023DJ02 A0A023P4U3 A0A024P4L1 A0A024P5Z1 A0A024P747 A0A024P926
    (997 more...)
    DTDP-4-amino-4,6-dideoxy-D-glucose transaminase. [EC: 2.6.1.33]
    dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4- dehydro-6-deoxy-alpha-D-glucose + L-glutamate.
      		 16 A0A0E1X112 A0A0F6ASH3 A0A0H3G960 A0A0M1W9U8 A0A0M2YA97 C0G8L3 C0RF81 C4IT35 C4WJ43 C7LE63
      (6 more...)
      Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)). [EC: 1.2.1.9]
      D-glyceraldehyde 3-phosphate + NADP(+) + H(2)O = 3-phospho-D-glycerate + NADPH.
        		 8 A0A0H1TVX8 A0A0T8FKU8 A0A0T8L3D6 A0A0T8YD07 A0A111T132 A0A125W2F5 A0A137Y7X1 X5NU75
        Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
        An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
        • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
        • Formerly EC 1.1.1.70.
        		 1 A0A170ZJA1
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