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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17384: Gamma-aminobutyraldehyde dehydrogenase domain prot...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH.
  • The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates.
  • The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54).
  • As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate.
  • Formerly EC 1.5.1.35.
 683 A0A017IHI3 A0A023VBX2 A0A023YX98 A0A024KWA8 A0A024L2W8 A0A025C6D6 A0A026S7S1 A0A026V333 A0A027TJJ1 A0A027ZLX2
(673 more...)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
  • In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine.
  • This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria.
  • In contrast, different enzymes are involved in the first reaction.
  • In plants, this reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC 1.1.99.1 or soluble EC 1.1.3.17.
  • In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.
 3 B3WXY5 F3V5J7 F5N160