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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12194: Sulfoacetaldehyde dehydrogenase (acylating)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sulfoacetaldehyde dehydrogenase (acylating). [EC: 1.2.1.81]
2-sulfoacetaldehyde + CoA + NADP(+) = sulfoacetyl-CoA + NADPH.
  • The enzyme is involved in degradation of sulfoacetate.
  • In this pathway the reaction is catalyzed in the reverse direction.
  • The enzyme is specific for sulfoacetaldehyde and NADP(+).
 2 A0A1K0IP04 Q0K845
Succinate-semialdehyde dehydrogenase (acetylating). [EC: 1.2.1.76]
Succinate semialdehyde + CoA + NADP(+) = succinyl-CoA + NADPH.
  • Catalyzes the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.
  • The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation, and in Metallosphaera sedula, where it participates in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
 1 G0ESE9
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