The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 80093: Glutathione S-transferase Mu 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 48 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
45 A7E2P6 (/IDA) B8JIS5 (/IDA) B8JIS6 (/IDA) B8JIS8 (/IDA) C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA) C8BLR6 (/IDA)
(35 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
27 G5EC71 (/ISS) O18879 (/ISS) P09210 (/ISS) P10648 (/ISS) P13745 (/ISS) P24472 (/ISS) P26697 (/ISS) P30115 (/ISS) P51781 (/ISS) P80894 (/ISS)
(17 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 O15217 (/IPI) O60760 (/IPI) P09210 (/IPI) P09211 (/IPI) P10299 (/IPI) P10649 (/IPI) P19157 (/IPI) P28161 (/IPI) P46439 (/IPI) P48774 (/IPI)
(5 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
14 O15217 (/TAS) O60760 (/TAS) P08010 (/TAS) P08263 (/TAS) P09210 (/TAS) P09211 (/TAS) P09488 (/TAS) P21266 (/TAS) P24472 (/TAS) P28161 (/TAS)
(4 more)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
12 P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04905 (/IDA) P04906 (/IDA) P08010 (/IDA) P09488 (/IDA) P14942 (/IDA) P21266 (/IDA) P28161 (/IDA)
(2 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
10 P10649 (/ISO) P15626 (/ISO) P19157 (/ISO) P19639 (/ISO) P24472 (/ISO) P46425 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO) Q9JHF7 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
8 P00502 (/IDA) P04905 (/IDA) P08010 (/IDA) P10649 (/IDA) P15626 (/IDA) P21266 (/IDA) P48774 (/IDA) Q9Z1B2 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
6 P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04906 (/IDA) P14942 (/IDA) P46418 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 O15217 (/IPI) O60760 (/IPI) P09488 (/IPI) P21266 (/IPI) P28161 (/IPI) Q03013 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 P15626 (/ISO) P19639 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO) Q9JHF7 (/ISO)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
5 P08263 (/IDA) P09211 (/IDA) P28161 (/IDA) P41043 (/IDA) P46436 (/IDA)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
4 P04905 (/IMP) P08010 (/IMP) P30115 (/IMP) Q9N4X8 (/IMP)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 P09488 (/IPI) P21266 (/IPI) P28161 (/IPI) Q03013 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
4 P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 O35543 (/ISS) O73888 (/ISS) Q9JHF7 (/ISS)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
3 P08263 (/NAS) P41043 (/NAS) Q09607 (/NAS)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
3 P19157 (/ISO) P46425 (/ISO) Q80W21 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 O35543 (/ISS) O73888 (/ISS) Q9JHF7 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 O15217 (/IPI) P21266 (/IPI) P46439 (/IPI)
Prostaglandin-D synthase activity GO:0004667
Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
2 O60760 (/IDA) Q9JHF7 (/IDA)
Prostaglandin-D synthase activity GO:0004667
Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
2 O35543 (/ISS) O73888 (/ISS)
Prostaglandin-D synthase activity GO:0004667
Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
2 O35543 (/TAS) O60760 (/TAS)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
2 P04906 (/ISS) P09211 (/ISS)
Kinase regulator activity GO:0019207
Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 P04906 (/ISS) P09211 (/ISS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P04905 (/IPI) P04906 (/IPI)
S-nitrosoglutathione binding GO:0035730
Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.
2 P19157 (/ISO) P46425 (/ISO)
Dinitrosyl-iron complex binding GO:0035731
Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.
2 P19157 (/ISO) P46425 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P10649 (/ISO) P48774 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P10649 (/IDA) P15626 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 O60760 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9JHF7 (/ISO)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 P13745 (/ISA)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
1 Q09607 (/ISS)
Prostaglandin-D synthase activity GO:0004667
Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
1 O60760 (/EXP)
Prostaglandin-D synthase activity GO:0004667
Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
1 Q9JHF7 (/ISO)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P28161 (/IPI)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q80W21 (/ISO)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
1 P04905 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 O60760 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9JHF7 (/ISO)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P19157 (/ISS)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
1 P19157 (/IPI)
Nickel cation binding GO:0016151
Interacting selectively and non-covalently with nickel (Ni) cations.
1 P04905 (/IDA)
Kinase regulator activity GO:0019207
Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P19157 (/IMP)
S-nitrosoglutathione binding GO:0035730
Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.
1 P09211 (/IDA)
Dinitrosyl-iron complex binding GO:0035731
Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.
1 P09211 (/IDA)
Nitric oxide binding GO:0070026
Interacting selectively and non-covalently with nitric oxide (NO).
1 P09211 (/NAS)

There are 160 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
27 O18879 (/ISS) P09210 (/ISS) P10648 (/ISS) P13745 (/ISS) P24472 (/ISS) P26697 (/ISS) P30115 (/ISS) P48774 (/ISS) P51781 (/ISS) P80894 (/ISS)
(17 more)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
15 O15217 (/IDA) P04905 (/IDA) P08263 (/IDA) P09211 (/IDA) P09488 (/IDA) P19157 (/IDA) P21266 (/IDA) P28161 (/IDA) P41043 (/IDA) P46425 (/IDA)
(5 more)
Xenobiotic catabolic process GO:0042178
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
11 P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04905 (/IDA) P08010 (/IDA) P09488 (/IDA) P21266 (/IDA) P28161 (/IDA) P46418 (/IDA) Q03013 (/IDA)
(1 more)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
11 O15217 (/TAS) O60760 (/TAS) P08263 (/TAS) P09210 (/TAS) P09211 (/TAS) P09488 (/TAS) P21266 (/TAS) P28161 (/TAS) P46439 (/TAS) Q03013 (/TAS)
(1 more)
Aflatoxin B1 metabolic process GO:0043390
The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi.
8 C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA) C8BLR6 (/IDA) D4N2R6 (/IDA) G8HHE8 (/IDA)
Detoxification GO:0098754
Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
8 C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA) C8BLR6 (/IDA) D4N2R6 (/IDA) G8HHE8 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
6 O45451 (/IEP) P91252 (/IEP) P91253 (/IEP) Q09596 (/IEP) Q22814 (/IEP) Q93694 (/IEP)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
5 P10649 (/ISO) P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
5 P00502 (/IEP) P04903 (/IEP) P04904 (/IEP) P08010 (/IEP) P46418 (/IEP)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
4 O15217 (/IDA) P04906 (/IDA) P09211 (/IDA) P14942 (/IDA)
Nitrobenzene metabolic process GO:0018916
The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline.
4 P09488 (/IDA) P21266 (/IDA) P28161 (/IDA) Q8R5I6 (/IDA)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
4 P00502 (/IEP) P04904 (/IEP) P04906 (/IEP) P46418 (/IEP)
Xenobiotic catabolic process GO:0042178
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
4 P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
3 P19157 (/ISS) Q28514 (/ISS) Q60550 (/ISS)
Metabolic process GO:0008152
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
3 P08263 (/IC) P41043 (/IC) Q09607 (/IC)
Nitrobenzene metabolic process GO:0018916
The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline.
3 P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 P00502 (/NAS) P04904 (/NAS) P46418 (/NAS)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
3 P08263 (/IDA) P09211 (/IDA) P28161 (/IDA)
Cellular detoxification of nitrogen compound GO:0070458
Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
3 P09488 (/IDA) P21266 (/IDA) P28161 (/IDA)
Cellular detoxification of nitrogen compound GO:0070458
Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
3 P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
2 P04906 (/ISS) P09211 (/ISS)
Negative regulation of acute inflammatory response GO:0002674
Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
2 P09211 (/NAS) P19157 (/NAS)
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
2 O60760 (/IDA) Q9JHF7 (/IDA)
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
2 O35543 (/ISS) O73888 (/ISS)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
2 P04906 (/TAS) P08010 (/TAS)
Negative regulation of biosynthetic process GO:0009890
Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
2 P09211 (/IDA) P19157 (/IDA)
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
2 P04905 (/IEP) P08010 (/IEP)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
2 P08263 (/IEP) P09210 (/IEP)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
2 P09211 (/IDA) P19157 (/IDA)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
2 P09211 (/IDA) P19157 (/IDA)
Regulation of stress-activated MAPK cascade GO:0032872
Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
2 P04906 (/ISS) P09211 (/ISS)
Negative regulation of stress-activated MAPK cascade GO:0032873
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
2 P04906 (/ISS) P09211 (/ISS)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
2 P04906 (/ISS) P09211 (/ISS)
Response to stilbenoid GO:0035634
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
2 P10648 (/IEP) P13745 (/IEP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P10649 (/IDA) P19639 (/IDA)
Common myeloid progenitor cell proliferation GO:0035726
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
2 P04906 (/ISS) P09211 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P09211 (/TAS) P19157 (/TAS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2 P04906 (/ISS) P09211 (/ISS)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
2 P04905 (/IEP) P04906 (/IEP)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
2 P09211 (/IDA) P19157 (/IDA)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
2 P04905 (/IEP) P04906 (/IEP)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 P04906 (/ISS) P09211 (/ISS)
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
2 P09211 (/IDA) P19157 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 G5EC71 (/ISS) Q09607 (/ISS)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P04906 (/ISS) P09211 (/ISS)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P09211 (/IDA) P19157 (/IDA)
Negative regulation of leukocyte proliferation GO:0070664
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
2 P04906 (/ISS) P09211 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P04906 (/ISS) P09211 (/ISS)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
2 P09211 (/IDA) P19157 (/IDA)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P19157 (/IDA)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 Q9NA96 (/IMP)
Prostaglandin biosynthetic process GO:0001516
The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
1 O35543 (/TAS)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 P30115 (/IEP)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P09211 (/IDA)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P04906 (/IMP)
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
1 Q9JHF7 (/ISO)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
1 P13745 (/ISA)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
1 Q9N4X8 (/TAS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P41043 (/NAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 O60760 (/NAS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P09211 (/TAS)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 O60760 (/TAS)
Establishment of blood-nerve barrier GO:0008065
The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.
1 P21266 (/TAS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 G5EC71 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9N4X8 (/IMP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P14942 (/IEP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 P04906 (/IEP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 Q50LC6 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 P19157 (/ISS)
Negative regulation of biosynthetic process GO:0009890
Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
1 P04906 (/ISS)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P14942 (/IEP)
Response to UV-C GO:0010225
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.
1 Q9N4X8 (/IMP)
Response to lithium ion GO:0010226
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
1 P04905 (/IEP)
Heat acclimation GO:0010286
Any process that increases heat tolerance of an organism in response to high temperatures.
1 Q9N4X8 (/IMP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P04905 (/IEP)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
1 P09211 (/IC)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880
Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
1 P28161 (/IDA)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880
Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
1 Q80W21 (/ISO)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881
Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
1 P28161 (/IC)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
1 P04906 (/IEP)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
1 P19157 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P08010 (/IEP)
Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion GO:0014809
Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
1 P28161 (/IC)
Cyclooxygenase pathway GO:0019371
The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
1 O60760 (/TAS)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P04906 (/IEP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P19157 (/ISS)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P19157 (/ISS)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P04906 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P19157 (/ISS)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 P04906 (/ISS)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 P04906 (/ISS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P04906 (/IEP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P19157 (/ISS)
Regulation of stress-activated MAPK cascade GO:0032872
Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 P19157 (/IDA)
Negative regulation of stress-activated MAPK cascade GO:0032873
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 P19157 (/IDA)
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
1 P19157 (/IMP)
Response to L-ascorbic acid GO:0033591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.
1 P04906 (/IEP)
Response to L-ascorbic acid GO:0033591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.
1 P19157 (/ISS)
Response to genistein GO:0033595
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.
1 P08010 (/IEP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P09211 (/TAS)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 P14942 (/IEP)
Common myeloid progenitor cell proliferation GO:0035726
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
1 P19157 (/IMP)
Nitric oxide storage GO:0035732
The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.
1 P09211 (/NAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P04905 (/IEP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q9N4X8 (/IMP)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P19157 (/IDA)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 P19157 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P09211 (/TAS)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
1 P09211 (/IDA)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
1 P19157 (/ISS)
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
1 P09211 (/NAS)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
1 P19157 (/IMP)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
1 P04906 (/ISS)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 P21266 (/IEP)
Linoleic acid metabolic process GO:0043651
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
1 Q80W21 (/ISO)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 P10299 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P19157 (/ISS)
Aflatoxin catabolic process GO:0046223
The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
1 P30115 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P04905 (/IEP)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 P19157 (/IMP)
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
1 P04905 (/IEP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 P10299 (/IMP)
Negative regulation of nitric-oxide synthase biosynthetic process GO:0051771
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.
1 P04906 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P46436 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q9N4X8 (/IMP)
Relaxation of cardiac muscle GO:0055119
The process in which the extent of cardiac muscle contraction is reduced.
1 P28161 (/TAS)
Negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315
Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
1 P28161 (/IDA)
Negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315
Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
1 Q80W21 (/ISO)
Positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316
Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
1 P28161 (/IDA)
Positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316
Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
1 Q80W21 (/ISO)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P19157 (/IDA)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P04906 (/ISS)
Negative regulation of leukocyte proliferation GO:0070664
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
1 P19157 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P19157 (/IDA)
Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
1 P14942 (/IEP)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
1 P28161 (/IDA)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
1 Q80W21 (/ISO)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 P04906 (/IEP)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 P19157 (/ISS)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P04906 (/IEP)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P19157 (/ISS)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P19639 (/IDA)
Cellular response to cell-matrix adhesion GO:0071460
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.
1 P04906 (/IEP)
Cellular response to cell-matrix adhesion GO:0071460
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.
1 P19157 (/ISS)
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 Q9DDU5 (/IDA)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
1 P04906 (/ISS)
Negative regulation of smooth muscle cell chemotaxis GO:0071672
Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.
1 P04906 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P10299 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P10299 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 P10299 (/IGI)
Response to catechin GO:1902168
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus.
1 P08010 (/IEP)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 P04906 (/IMP)
Negative regulation of cellular response to manganese ion GO:1905803
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion.
1 P10299 (/IGI)
Positive regulation of cellular response to manganese ion GO:1905804
Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion.
1 P10299 (/IGI)
Positive regulation of cellular response to manganese ion GO:1905804
Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion.
1 P10299 (/IMP)
Negative regulation of male germ cell proliferation GO:2000255
Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation.
1 Q9JHF7 (/IGI)
Negative regulation of neutrophil aggregation GO:2000429
Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation.
1 P19157 (/NAS)
Negative regulation of peroxidase activity GO:2000469
Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity.
1 P19157 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 P09211 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 P19157 (/ISS)

There are 47 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
21 C8BLR1 (/IDA) C8BLR2 (/IDA) C8BLR3 (/IDA) C8BLR4 (/IDA) C8BLR5 (/IDA) C8BLR6 (/IDA) D4N2R6 (/IDA) G8HHE8 (/IDA) P00502 (/IDA) P04903 (/IDA)
(11 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 O15217 (/TAS) O60760 (/TAS) P08263 (/TAS) P09210 (/TAS) P09211 (/TAS) P09488 (/TAS) P21266 (/TAS) P28161 (/TAS) P46439 (/TAS) Q03013 (/TAS)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P04906 (/IDA) P09488 (/IDA) P14942 (/IDA) P21266 (/IDA) P28161 (/IDA) P46436 (/IDA) Q03013 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
7 P08263 (/IDA) P09210 (/IDA) P09211 (/IDA) P21266 (/IDA) P28161 (/IDA) Q16772 (/IDA) Q7RTV2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
7 P10648 (/ISO) P13745 (/ISO) P19157 (/ISO) P30115 (/ISO) P46425 (/ISO) P48774 (/ISO) Q80W21 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P04906 (/IDA) P21266 (/IDA) P46418 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P10648 (/ISO) P13745 (/ISO) P19157 (/ISO) P30115 (/ISO) P46425 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Dendritic knob GO:0098788
The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium.
5 A0A060X8J1 (/ISS) B5XBZ2 (/ISS) B5XGZ2 (/ISS) L7QI61 (/ISS) Q9W647 (/ISS)
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
4 P00502 (/IDA) P04903 (/IDA) P04904 (/IDA) P46418 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P15626 (/ISO) P48774 (/ISO) Q80W21 (/ISO) Q8R5I6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 G5EC71 (/ISS) P19157 (/ISS) P41043 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P09211 (/IDA) P14942 (/IDA) V9HWE9 (/IDA)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
3 P04905 (/IDA) P08010 (/IDA) P19157 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P09211 (/IDA) Q08392 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P19157 (/ISO) P46425 (/ISO)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 P09211 (/IDA) P19157 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 P19157 (/ISO) P46425 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O60760 (/TAS) P09211 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P19157 (/ISO) P46425 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P04906 (/IDA) P08010 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 P19157 (/ISO) P46425 (/ISO)
TRAF2-GSTP1 complex GO:0097057
A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.
2 P19157 (/ISO) P46425 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P04905 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P09211 (/TAS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 P04906 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P48774 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P19157 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P19157 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P19157 (/ISS)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 P46436 (/IDA)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
1 P28161 (/IDA)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
1 Q80W21 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 P09211 (/IDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 P09211 (/TAS)
Sperm fibrous sheath GO:0035686
A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.
1 P48774 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P10649 (/IDA)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
1 P04906 (/ISS)
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
1 Q21355 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 A0A060WT29 (/IDA)
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
1 A0A060WT29 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 A0A060WT29 (/IDA)
TRAF2-GSTP1 complex GO:0097057
A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.
1 P09211 (/IDA)
Dendritic knob GO:0098788
The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium.
1 A0A060WT29 (/IDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 P09211 (/TAS)