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CATH Superfamily 3.40.30.10

Glutaredoxin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79955: Protein SCO1 homolog, mitochondrial

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Classical-complement-pathway C3/C5 convertase. [EC: 3.4.21.43]
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
  • A complex of complement fragments C4b, C2a and C2b.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.44.
 22 A0A0D2K2K8 A0A0D2K2K8 A0A0D6EW95 A0A0D6EW95 A0A0X8R015 A0A0X8R015 A7HP04 A7HP04 B7P8T9 B7P8T9
(12 more...)
Cytochrome-c oxidase. [EC: 1.9.3.1]
4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
  • The reduction of O(2) to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
  • Several bacteria appear to contain analogous oxidases.
 14 A0A088RI21 A0A088RI21 A0A1E1INS9 A0A1E1INS9 A4H427 A4H427 A4HSB1 A4HSB1 B4I196 B4I196
(4 more...)
Peroxiredoxin. [EC: 1.11.1.15]
2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule.
 2 A0A0C1EEL3 A0A0C1EEL3
Arginine decarboxylase. [EC: 4.1.1.19]
L-arginine = agmatine + CO(2).
    		 2 U2WT51 U2WT51
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