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CATH Superfamily 3.40.30.10

Glutaredoxin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79826: Thioredoxin reductase 1, cytoplasmic

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thioredoxin-disulfide reductase. [EC: 1.8.1.9]
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
  • May be identical to EC 1.8.1.10.
  • Formerly EC 1.6.4.5.
 8 A0A060T8Z1 A0A060T8Z1 A0A125RTZ2 A0A125RTZ2 Q86VQ6 Q86VQ6 Q99MD6 Q99MD6
Arsenate reductase (glutaredoxin). [EC: 1.20.4.1]
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
  • The enzyme is part of a system for detoxifying arsenate.
  • Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4).
  • Formerly EC 1.97.1.5.
 6 A0A060T839 A0A060T839 D8LC00 D8LC00 D8LSE4 D8LSE4
Glutathione-disulfide reductase. [EC: 1.8.1.7]
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
  • Activity is dependent on a redox-active disulfide in each of the active centers.
  • Formerly EC 1.6.4.2.
 2 E0VD04 E0VD04
Adenylyl-sulfate reductase (glutathione). [EC: 1.8.4.9]
AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione.
  • Differs from EC 1.8.99.2, in using glutathione as the reductant.
  • Glutathione can be replaced by gamma-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or mercaptoethanol.
  • The enzyme from Arabidopsis thaliana contains a glutaredoxin-like domain.
  • Also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Enteromorpha intestinalis.
 2 M2W7R1 M2W7R1