The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Glutaredoxin
".
FunFam 79775: Glutaredoxin-3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | O74790 (/IPI) O76003 (/IPI) Q9CQM9 (/IPI) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | O76003 (/IDA) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q9CQM9 (/ISO) |
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | Q9JLZ1 (/IDA) |
Glutathione disulfide oxidoreductase activity GO:0015038
Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
|
1 | O74790 (/IMP) |
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
1 | O74790 (/IDA) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
3 | Q28ID3 (/ISS) Q9CQM9 (/ISS) Q9JLZ1 (/ISS) |
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
|
3 | Q28ID3 (/ISS) Q9CQM9 (/ISS) Q9JLZ1 (/ISS) |
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
|
2 | O76003 (/ISS) Q58DA7 (/ISS) |
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
2 | O76003 (/ISS) Q58DA7 (/ISS) |
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
|
1 | Q9CQM9 (/IMP) |
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
1 | O74790 (/IGI) |
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
|
1 | O74790 (/IMP) |
Negative regulation of cardiac muscle hypertrophy GO:0010614
Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
1 | Q9CQM9 (/IMP) |
Hemoglobin metabolic process GO:0020027
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
|
1 | Q5XJ54 (/IGI) |
Hemoglobin metabolic process GO:0020027
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
|
1 | Q5XJ54 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | O74790 (/NAS) |
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
1 | O76003 (/IDA) |
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
|
1 | Q9CQM9 (/ISO) |
Cytoplasmic sequestering of protein GO:0051220
The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.
|
1 | O74790 (/IMP) |
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
|
1 | Q5XJ54 (/IMP) |
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
|
1 | O76003 (/IDA) |
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
|
1 | Q9CQM9 (/ISO) |
Negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026
Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
|
1 | O74790 (/IMP) |
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
|
1 | O74790 (/NAS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O74790 (/IDA) Q9JLZ1 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O74790 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O74790 (/IDA) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | Q9CQM9 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q9JLZ1 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | O76003 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9CQM9 (/ISO) |