The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine Aminopeptidase, subunit E, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5155: Probable cytosol aminopeptidase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Leucyl aminopeptidase. [EC: 3.4.11.1]
Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
  • Is activated by heavy metal ions.
  • Belongs to peptidase family M17.
  • Formerly EC 3.4.1.1.
1447 A0A011TAU2 A0A011TS14 A0A017PJT5 A0A021WZJ7 A0A021X0J6 A0A023XGC4 A0A024INR9 A0A024KFF8 A0A031HIC5 A0A031JHH9
(1437 more...)
Bacterial leucyl aminopeptidase. [EC: 3.4.11.10]
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
  • Similar aminopeptidases were isolated from Escherichia coli and Staphylococcus thermophilus.
  • Belongs to peptidase families M17 and M28.
1436 A0A011TAU2 A0A011TS14 A0A017PJT5 A0A021WZJ7 A0A021X0J6 A0A023XGC4 A0A024INR9 A0A024KFF8 A0A031HIC5 A0A031JHH9
(1426 more...)
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