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CATH Superfamily 3.40.220.10

Leucine Aminopeptidase, subunit E, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine Aminopeptidase, subunit E, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4938: Probable cytosol aminopeptidase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Leucyl aminopeptidase. [EC: 3.4.11.1]
Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
  • Is activated by heavy metal ions.
  • Belongs to peptidase family M17.
  • Formerly EC 3.4.1.1.
 25 A0A058YQF2 A0A063U5B9 A0A0A0XJ79 A0A0C6PA43 A0A0D6GM35 A0A0H4W6Z9 A0A0J6CCC2 A0A0M7EUA5 A0A0M7M9Z6 A0A0M9IAE8
(15 more...)
Bacterial leucyl aminopeptidase. [EC: 3.4.11.10]
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
  • Similar aminopeptidases were isolated from Escherichia coli and Staphylococcus thermophilus.
  • Belongs to peptidase families M17 and M28.
 25 A0A058YQF2 A0A063U5B9 A0A0A0XJ79 A0A0C6PA43 A0A0D6GM35 A0A0H4W6Z9 A0A0J6CCC2 A0A0M7EUA5 A0A0M7M9Z6 A0A0M9IAE8
(15 more...)