The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Severin
".
FunFam 5438: Putative uncharacterized protein SCIN
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
|
1 | Q28046 (/IDA) |
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
|
1 | Q9Y6U3 (/ISS) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q28046 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q9Y6U3 (/ISS) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q9Y6U3 (/TAS) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q28046 (/IDA) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q9Y6U3 (/ISS) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q9Y6U3 (/TAS) |
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
1 | Q9Y6U3 (/TAS) |
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
|
1 | Q28046 (/IDA) |
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
|
1 | Q9Y6U3 (/ISS) |
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q28046 (/IDA) |
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q9Y6U3 (/ISS) |
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of chondrocyte differentiation GO:0032330
Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
|
3 | Q28046 (/ISS) Q60604 (/ISS) Q9Y6U3 (/ISS) |
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q9Y6U3 (/IMP) |
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q60604 (/ISO) |
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q28046 (/ISS) |
Calcium ion regulated exocytosis GO:0017156
The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
|
1 | Q28046 (/IDA) |
Calcium ion regulated exocytosis GO:0017156
The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
|
1 | Q9Y6U3 (/ISS) |
Regulation of chondrocyte differentiation GO:0032330
Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
|
1 | Q5ZIV9 (/IDA) |
Sequestering of actin monomers GO:0042989
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
|
1 | Q9Y6U3 (/IMP) |
Sequestering of actin monomers GO:0042989
The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.
|
1 | Q60604 (/ISO) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q9Y6U3 (/IMP) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q60604 (/ISO) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q28046 (/ISS) |
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
|
1 | Q28046 (/IDA) |
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
|
1 | Q9Y6U3 (/ISS) |
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
|
1 | Q9Y6U3 (/IMP) |
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
|
1 | Q60604 (/ISO) |
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
|
1 | Q28046 (/ISS) |
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
|
1 | Q28046 (/IDA) |
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
|
1 | Q9Y6U3 (/IMP) |
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
|
1 | Q60604 (/ISO) |
Positive regulation of secretion GO:0051047
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
|
1 | Q28046 (/IDA) |
Positive regulation of secretion GO:0051047
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
|
1 | Q9Y6U3 (/ISS) |
Positive regulation of actin nucleation GO:0051127
Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
|
1 | Q9Y6U3 (/IMP) |
Positive regulation of actin nucleation GO:0051127
Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
|
1 | Q60604 (/ISO) |
Actin filament capping GO:0051693
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
|
1 | Q9Y6U3 (/IMP) |
Actin filament capping GO:0051693
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
|
1 | Q60604 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q28046 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9Y6U3 (/ISS) |
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
|
1 | Q60604 (/IDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q28046 (/IDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q9Y6U3 (/ISS) |
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
1 | E9PU64 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9Y6U3 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q60604 (/ISO) |