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CATH Superfamily 3.40.1780.10

QueA-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
QueA-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3379: Putative S-adenosylmethionine:tRNA ribosyltransfer...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
S-adenosylmethionine:tRNA ribosyltransferase-isomerase. [EC: 2.4.99.17]
S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.
  • The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn.
  • It is part of the queuosine biosynthesis pathway.
 26 A0A0F3QCN2 A0A0F3QGX5 A0A0G0ARD5 A0A0G0HBX7 A0A0P6XQ67 A0A0T6A3D6 A0A117L2N7 A0A117L9G3 A0A1F6LNZ2 A0A1F6M8G7
(16 more...)
TRNA-guanine(34) transglycosylase. [EC: 2.4.2.29]
(1) Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine. (2) Guanine(34) in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7- carbaguanine(34) in tRNA + guanine.
  • Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
  • In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine.
  • In eubacteria, which produce queuine de novo, the enzyme catalyzes the exchange of guanine with the queuine precursor preQ(1), which is ultimately modified to queuine.
  • The eubacterial enzyme can also use an earlier intermediate, preQ(0), to replace guanine in unmodified tRNA(Tyr) and tRNA(Asn).
  • This enzyme acts after EC 1.7.1.13 in the queuine-biosynthesis pathway.
 1 F9DKS8
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