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CATH Superfamily 3.40.1390.10

MurE/MurF, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
MurE/MurF, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3928: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-dia...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. [EC: 6.3.2.7]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
 671 A0A022N634 A0A024DEY7 A0A059N1Z4 A0A060RHN3 A0A064C357 A0A072EW59 A0A074IUQ2 A0A075SK59 A0A076GSH1 A0A076JGU4
(661 more...)
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. [EC: 6.3.2.13]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead.
  • It is the amino group of the L-center of the diaminopimelate that is acylated.
 218 A0A072R201 A0A081CRD1 A0A084SQ47 A0A085B4I6 A0A085VZV8 A0A094P7B1 A0A094PLX7 A0A094RRZ6 A0A094S335 A0A096KJN7
(208 more...)
Acetylglutamate kinase. [EC: 2.7.2.8]
ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.
    		 5 A0A0S2VZK8 A0A1C5PKN2 A0A1C6A6W1 A0A1C6CWX8 A0A1C6GGN2
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase. [EC: 6.3.2.10]
    ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl- D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysyl-D-alanyl-D-alanine.
    • Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide.
    • Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center.
    • Formerly EC 6.3.2.15.
    		 1 A0A095YFY9
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