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CATH Superfamily 3.40.1390.10

MurE/MurF, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
MurE/MurF, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3873: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-dia...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. [EC: 6.3.2.13]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead.
  • It is the amino group of the L-center of the diaminopimelate that is acylated.
 1487 A0A015QV67 A0A015SUY8 A0A015TN22 A0A015TQ00 A0A015TZX7 A0A015W385 A0A015WP19 A0A015X8Z5 A0A015YRU5 A0A016AHQ9
(1477 more...)
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. [EC: 6.3.2.7]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
 8 A0A0E9EE61 A0A0U2UL30 A0A1E7S3X7 A0A1F2PJ54 A0A1M4N9X7 A0A1M7AQ85 E3GIM1 H6LB87
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase. [EC: 6.3.2.10]
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl- D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysyl-D-alanyl-D-alanine.
  • Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide.
  • Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center.
  • Formerly EC 6.3.2.15.
 3 A0A1J5HZM3 B4SHE8 R7RNQ5
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