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CATH Superfamily 3.40.1390.10

MurE/MurF, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
MurE/MurF, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3805: UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diamin...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. [EC: 6.3.2.7]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
 132 A0A077UJW2 A0A0D1HPY4 A0A0E0VP05 A0A0E1AIW6 A0A0E1VFQ2 A0A0E1VKS0 A0A0E1X6V3 A0A0E2MZ96 A0A0E7MX78 A0A0H2I7X0
(122 more...)
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. [EC: 6.3.2.13]
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.
  • Involved in the synthesis of a cell-wall peptide.
  • This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead.
  • It is the amino group of the L-center of the diaminopimelate that is acylated.
 5 A0A1K9Q3H5 A0A1M4Q1J2 A0A1M4Q1W0 A0A1M4Q4F6 Q8NXC2
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