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CATH Superfamily 3.40.1350.30

(Uracil-5)-methyltransferase, central domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: (Uracil-5)-methyltransferase, central domain

Post-transcriptional modifications of nucleotides in RNA are present in all kingdoms of life. These occur in many types of RNAs, including tRNA, rRNA, mRNA, snRNA, snoRNA, and tmRNA. A common modification found in RNA is the substitution of 5-methyluridine (m5U) for uridine. This modification is catalysed by S-adenosylmethionine (SAM)-dependent m5U methyltransferases (MTases). The MTase is divided into three different domains: the N-terminal, catalytic and central domains. This entry represents the central domain which is made up of a six-stranded beta-sheet combined with three alpha-helices. It contains an iron-sulphur cluster PMID:15016356 .

GO Diversity

Unique GO annotations
21 Unique GO terms

EC Diversity

Unique EC annotations
6 Unique EC terms

Species Diversity

Unique species annotations
10934 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 7
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 5
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 6
Unique GO: 21
Taxonomy
Unique Species: 10934