View in Gene3D

CATH Superfamily 3.40.1280.10

SPOUT methyltransferase, trefoil knot domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 12744: tRNA (guanine-N(1)-)-methyltransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanine(37)-N(1))-methyltransferase. [EC: 2.1.1.228]
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
  • This enzyme is important for the maintenance of the correct reading frame during translation.
  • Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37.
  • Formerly EC 2.1.1.31.
 53 A0A067AC61 A0A0B7J3B0 A0A0C2M0T7 A0A0F3MJ68 A0A0F3MNV4 A0A0F3MP95 A0A0F3MQR0 A0A0F3N0N1 A0A0F3P2I7 A0A0F3P4Y5
(43 more...)
CATH-Gene3D is a Global Biodata Core Resource Learn more...