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CATH Superfamily 3.40.1190.20

Ribokinase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16764: Bifunctional NAD(P)H-hydrate repair enzyme Nnr

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NAD(P)H-hydrate epimerase. [EC: 5.1.99.6]
(1) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide. (2) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate.
  • The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.
  • Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93.
 249 A0A024BXD0 A0A024C136 A0A060PZR6 A0A083YFW3 A0A086RS16 A0A0B2E0P5 A0A0B2E379 A0A0B2E8R1 A0A0B2EDU2 A0A0B2EEI1
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ADP-dependent NAD(P)H-hydrate dehydratase. [EC: 4.2.1.136]
(1) ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine- dinucleotide = AMP + phosphate + NADH. (2) ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine- dinucleotide phosphate = AMP + phosphate + NADPH.
  • Acts equally well on hydrated NADH and hydrated NADPH.
  • NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers.
  • The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyzes the dehydration.
  • Hence the enzyme can restore the complete mixture of isomers into NAD(P)H.
  • The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93).
 92 A0A024C136 A0A0B2EEI1 A0A0B2EKK3 A0A0B2ER85 A0A0B2EZX4 A0A0K9MRE6 A0A0L0PKJ6 A0A0L0Q9U3 A0A0L6DBQ0 B5Z910
(82 more...)