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CATH Superfamily 3.40.1160.10

Acetylglutamate kinase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acetylglutamate kinase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9236: Delta-1-pyrroline-5-carboxylate synthase A

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutamate 5-kinase. [EC: 2.7.2.11]
ATP + L-glutamate = ADP + L-glutamate 5-phosphate.
  • The product rapidly cyclizes to 5-oxoproline and phosphate.
 39 A0A0B2P8V3 A0A0B2PDQ3 A0A0B2PJ53 A0A0B2PZW9 A0A0B2QMF0 A0A0J9S007 A0A0P9AMM0 A0A0R3P6N1 A0A178VF78 A0A178VY37
(29 more...)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]
L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.
    		 29 A0A061IBJ4 A0A0P9AMM0 A0A0R3P6N1 A0A178VF78 A0A178VY37 B3MAJ3 B3NJ19 B4L010 B4LHT5 B4N4G2
    (19 more...)
    L-glutamate gamma-semialdehyde dehydrogenase. [EC: 1.2.1.88]
    L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH.
    • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
    • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
    • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
    • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
    • NADP(+) can also act as acceptor, but with lower activity.
    • Formerly EC 1.5.1.12.
    		 1 A0A0U3E821
    Transferred entry: 1.2.1.88. [EC: 1.5.1.12]
      		1 Q8GUA9
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