The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Calcium-transporting ATPase, cytoplasmic domain N
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15545: Plasma membrane ATPase 1

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Proton-exporting ATPase. [EC: 3.6.3.6]
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • Generates an electrochemical potential gradient of protons across the plasma membrane.
  • Formerly EC 3.6.1.35.
3918 A0A010QC87 A0A010QC87 A0A010R1B9 A0A010R1B9 A0A015JVF6 A0A015JVF6 A0A015L147 A0A015L147 A0A015N343 A0A015N343
(3908 more...)
Magnesium-importing ATPase. [EC: 3.6.3.2]
ATP + H(2)O + Mg(2+)(Out) = ADP + phosphate + Mg(2+)(In).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
1288 A0A009PVU1 A0A009PVU1 A0A017I973 A0A017I973 A0A023Z6Y6 A0A023Z6Y6 A0A024HJ33 A0A024HJ33 A0A024KM31 A0A024KM31
(1278 more...)
Phospholipid-translocating ATPase. [EC: 3.6.3.1]
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • The enzyme apparently has several activities, one of them being the movement of phospholipids from one membrane face to the other.
  • Formerly EC 3.6.3.13.
258 A0A024KM31 A0A024KM31 A0A026UXN2 A0A026UXN2 A0A027U8Z1 A0A027U8Z1 A0A027ZXU3 A0A027ZXU3 A0A028DUH3 A0A028DUH3
(248 more...)
Calcium-transporting ATPase. [EC: 3.6.3.8]
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in Saccharomyces cerevisiae.
  • The first and third transport one ion per ATP hydrolyzed, whereas the second transports two ions.
  • Formerly EC 3.6.1.38.
46 A0A011QUT0 A0A011QUT0 A0A089QEY3 A0A089QEY3 A0A0M4RTM0 A0A0M4RTM0 A0A0P7IUE4 A0A0P7IUE4 A0A166KW82 A0A166KW82
(36 more...)
Cadmium-exporting ATPase. [EC: 3.6.3.3]
ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
14 A0A060A2T2 A0A060A2T2 A0A0A8K1K0 A0A0A8K1K0 A0A0E3QK14 A0A0E3QK14 A0A0E3QLR2 A0A0E3QLR2 A0A1E7YKE5 A0A1E7YKE5
(4 more...)
Zinc-exporting ATPase. [EC: 3.6.3.5]
ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • This enzyme also exports Cd(2+) and Co(2+).
14 A0A060A2T2 A0A060A2T2 A0A0A8K1K0 A0A0A8K1K0 A0A0E3QK14 A0A0E3QK14 A0A0E3QLR2 A0A0E3QLR2 A0A1E7YKE5 A0A1E7YKE5
(4 more...)
Beta-N-acetylgalactosaminidase. [EC: 3.2.1.53]
Hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.
    14 A0A0E1WXK4 A0A0E1WXK4 A0A0M1WFX5 A0A0M1WFX5 A0A1B3S1V0 A0A1B3S1V0 C0RJY9 C0RJY9 C4IU45 C4IU45
    (4 more...)
    Cu(2+)-exporting ATPase. [EC: 3.6.3.4]
    ATP + H(2)O + Cu(2+)(Side 1) = ADP + phosphate + Cu(2+)(Side 2).
    • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
    • The enzyme from the termophilic bacterium Archaeoglobus fulgidus is involved in copper extrusion from the cell.
    8 A0A0E3QK14 A0A0E3QK14 A0A0E3QLR2 A0A0E3QLR2 Q468L3 Q468L3 Q468L4 Q468L4
    Transferred entry: 3.6.3.6. [EC: 3.6.1.35]
      6 Q43107 Q43107 Q9M4N1 Q9M4N1 Q9M4N2 Q9M4N2
      Sodium-exporting ATPase. [EC: 3.6.3.7]
      ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).
      • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
      • Involved in the efflux of Na(+), with one ion being exported per ATP hydrolyzed.
      2 Q4WIM5 Q4WIM5
      Cu(+) exporting ATPase. [EC: 3.6.3.54]
      ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).
      • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
      • This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 3.6.3.4, which mainly transports the divalent copper ion.
      • Formerly EC 3.6.3.n1.
      2 A0A0A7LE15 A0A0A7LE15
      Hydrogen/potassium-exchanging ATPase. [EC: 3.6.3.10]
      ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
      • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
      • Hydrolysis of ATP is coupled with the exchange of H(+) and K(+) ions.
      • Formerly EC 3.6.1.36.
      2 A0A0F3HMP0 A0A0F3HMP0
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