The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Calcium-transporting ATPase, cytoplasmic domain N
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15339: Probable cation-transporting ATPase 13A2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9NQ11 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9NQ11 (/ISS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 Q9NQ11 (/NAS)
Cation-transporting ATPase activity GO:0019829
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
1 Q9NQ11 (/TAS)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 Q9NQ11 (/ISS)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q9NQ11 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q9CTG6 (/ISO)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
1 Q9NQ11 (/IDA)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
1 Q9CTG6 (/ISO)
Cupric ion binding GO:1903135
Interacting selectively and non-covalently with cupric ion, copper(2+).
1 Q9NQ11 (/ISS)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of mitochondrion organization GO:0010821
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
2 Q9CTG6 (/IMP) Q9NQ11 (/IMP)
Regulation of intracellular protein transport GO:0033157
Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
2 Q9CTG6 (/NAS) Q9NQ11 (/NAS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q9CTG6 (/IMP) Q9NQ11 (/IMP)
Zinc ion homeostasis GO:0055069
Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.
2 Q9CTG6 (/IMP) Q9NQ11 (/IMP)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
2 Q9CTG6 (/IMP) Q9NQ11 (/IMP)
Regulation of lysosomal protein catabolic process GO:1905165
Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.
2 Q9CTG6 (/IMP) Q9NQ11 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q9NQ11 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q9CTG6 (/ISO)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q9NQ11 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q9CTG6 (/ISO)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 Q9NQ11 (/IMP)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 Q9CTG6 (/ISO)
Regulation of mitochondrion organization GO:0010821
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
1 Q9NQ11 (/IDA)
Regulation of mitochondrion organization GO:0010821
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
1 Q9CTG6 (/ISO)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
1 Q9NQ11 (/IMP)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
1 Q9CTG6 (/ISO)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
1 Q9NQ11 (/TAS)
Regulation of autophagosome size GO:0016243
Any process that modulates the size of the autophagosome.
1 Q9NQ11 (/IDA)
Regulation of autophagosome size GO:0016243
Any process that modulates the size of the autophagosome.
1 Q9CTG6 (/ISO)
Cellular cation homeostasis GO:0030003
Any process involved in the maintenance of an internal steady state of cations at the level of a cell.
1 Q9NQ11 (/TAS)
Ion transmembrane transport GO:0034220
A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q9NQ11 (/TAS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q9CTG6 (/ISO)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q9NQ11 (/TAS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q9NQ11 (/TAS)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q9NQ11 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q9CTG6 (/ISO)
Regulation of endopeptidase activity GO:0052548
Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
1 Q9NQ11 (/IMP)
Regulation of endopeptidase activity GO:0052548
Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
1 Q9CTG6 (/ISO)
Zinc ion homeostasis GO:0055069
Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.
1 Q9CTG6 (/ISO)
Cellular response to manganese ion GO:0071287
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 Q9NQ11 (/IMP)
Cellular response to manganese ion GO:0071287
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 Q9CTG6 (/ISO)
Cellular response to manganese ion GO:0071287
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 Q9NQ11 (/TAS)
Cellular response to zinc ion GO:0071294
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q9NQ11 (/TAS)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q9NQ11 (/ISS)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q9NQ11 (/TAS)
Regulation of mitophagy GO:1903146
Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy).
1 Q9NQ11 (/TAS)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
1 Q9NQ11 (/IDA)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
1 Q9CTG6 (/ISO)
Regulation of chaperone-mediated autophagy GO:1904714
Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy.
1 Q9NQ11 (/TAS)
Autophagosome organization GO:1905037
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome.
1 Q9NQ11 (/IDA)
Autophagosome organization GO:1905037
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome.
1 Q9CTG6 (/ISO)
Polyamine import GO:1905122
The directed movement of polyamine macromolecule into a cell or organelle.
1 Q9NQ11 (/IDA)
Polyamine import GO:1905122
The directed movement of polyamine macromolecule into a cell or organelle.
1 Q9CTG6 (/ISO)
Regulation of glucosylceramidase activity GO:1905123
Any process that modulates the frequency, rate or extent of glucosylceramidase activity.
1 Q9CTG6 (/IMP)
Regulation of lysosomal protein catabolic process GO:1905165
Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.
1 Q9NQ11 (/IGI)
Regulation of lysosomal protein catabolic process GO:1905165
Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.
1 Q9CTG6 (/ISO)
Negative regulation of lysosomal protein catabolic process GO:1905166
Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.
1 Q9NQ11 (/TAS)
Peptidyl-aspartic acid autophosphorylation GO:1990938
The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein.
1 Q9NQ11 (/IMP)
Peptidyl-aspartic acid autophosphorylation GO:1990938
The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein.
1 Q9CTG6 (/ISO)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
2 Q8N4D4 (/IDA) Q9NQ11 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q9CTG6 (/IDA) Q9NQ11 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9CTG6 (/IDA) Q9NQ11 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q9NQ11 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q9CTG6 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q9CTG6 (/ISS)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 Q9CTG6 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 Q9NQ11 (/TAS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q9NQ11 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q9CTG6 (/ISO)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 Q9NQ11 (/IDA)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 Q9CTG6 (/ISO)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 Q9NQ11 (/TAS)
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
1 Q9NQ11 (/IDA)
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
1 Q9CTG6 (/ISO)
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
1 Q9CTG6 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9NQ11 (/NAS)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 Q9NQ11 (/IDA)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 Q9CTG6 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q9NQ11 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q9CTG6 (/ISO)
Multivesicular body membrane GO:0032585
The lipid bilayer surrounding a multivesicular body.
1 Q9NQ11 (/NAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9CTG6 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9CTG6 (/ISO)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
1 Q9NQ11 (/TAS)
Integral component of lysosomal membrane GO:1905103
The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9NQ11 (/IDA)
Integral component of lysosomal membrane GO:1905103
The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9CTG6 (/ISO)