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CATH Superfamily 3.40.1010.10

Tetrapyrrole methylase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cobalt-precorrin-4 Transmethylase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7306: Precorrin-2 C20-methyltransferase / cobalt-factor ...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Precorrin-2 C(20)-methyltransferase. [EC: 2.1.1.130]
S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A.
    		 33 A0A045JH32 A0A049EEE8 A0A083W4R5 A0A0E2WS29 A0A0E2X249 A0A0G4E456 A0A0H2ZT64 A0A0H3LEN5 A0A0H3M7N3 A0A0T9FWU6
    (23 more...)
    Precorrin-3B C(17)-methyltransferase. [EC: 2.1.1.131]
    S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4.
    • In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
    • The first of the four steps is carried out by EC 1.14.13.83 (CobG), yielding precorrin-3B as the product.
    • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.
    		 31 A0A045JH32 A0A049EEE8 A0A081HX54 A0A083W4R5 A0A0E2WS29 A0A0G4E456 A0A0H2ZT64 A0A0H3LEN5 A0A0H3M7N3 A0A0Q7LD33
    (21 more...)
    Cobalt-factor II C(20)-methyltransferase. [EC: 2.1.1.151]
    S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III.
    • Involved in the anaerobic biosynthesis of vitamin B12.
    		 2 A1UFX1 E6TI59
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