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CATH Superfamily 3.40.1010.10

Tetrapyrrole methylase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cobalt-precorrin-4 Transmethylase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4705: Cobalt-precorrin-6Y C(5)-methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Precorrin-6B C(5,15)-methyltransferase (decarboxylating). [EC: 2.1.1.132]
2 S-adenosyl-L-methionine + precorrin-6B = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO(2).
  • The enzyme, which participates in the aerobic adenosylcobalamin biosynthesis pathway, has S-adenosyl-L-methionine-dependent methyltransferase and decarboxylase activities.
  • The enzyme is a fusion protein with two active sites; one catalyzes the methylation at C(15) and the decarboxylation, while the other catalyzes the methylation at C(5).
 18 A0A0G2NPF9 A0A0H3BMZ8 A0A0N1QSQ3 A0A0R9NGJ7 A0A1L3M4W0 A0A1L3P241 A0A1L3PEZ1 B3YJU4 B5EWZ7 B5RBM1
(8 more...)
Cobalt-precorrin-7 (C(5))-methyltransferase. [EC: 2.1.1.289]
Cobalt-precorrin-7 + S-adenosyl-L-methionine = cobalt-precorrin-8 + S-adenosyl-L-homocysteine.
  • This enzyme catalyzes the methylation at C-5 of cobalt-precorrin-7, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.
 17 A0A0F6B375 A0A0F7DIW3 A0A0H2WMV1 A0A0H3NIE6 A0A0K6Q4V5 A0A0U1FRG3 A0A0W4R3Y5 A0A1J3YV36 A0A1J6ZLP9 A0A1L3UH40
(7 more...)