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CATH Superfamily 3.40.1010.10

Tetrapyrrole methylase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cobalt-precorrin-4 Transmethylase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3417: Cobalt-precorrin-4 C(11)-methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Precorrin-4 C(11)-methyltransferase. [EC: 2.1.1.133]
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5.
  • In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
  • The first of the four steps is carried out by EC 1.14.13.83 (CobG), yielding precorrin-3B as the product.
  • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.
 41 A0A060VEG3 A0A080SYV6 A0A085HWI9 A0A0A1RTK5 A0A0A5SXP2 A0A0B7GJX1 A0A0E1CE22 A0A0F5SC50 A0A0H3DRA0 A0A0H3GXL3
(31 more...)
Cobalt-precorrin-4 methyltransferase. [EC: 2.1.1.271]
S-adenosyl-L-methionine + cobalt-precorrin-4 = S-adenosyl-L-homocysteine + cobalt-precorrin-5A.
  • Part of the anaerobic route to adenosylcobalamin.
 14 A0A080SYV6 A0A0B7GJX1 A0A0H3GXL3 A0A0J2GLT8 A0A0M1TDU6 A0A0M2QSX3 A0A1D3KC98 A0A1E4ZER1 A0A1F2LT67 J2X5L7
(4 more...)
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