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CATH Superfamily 3.30.70.890

GHMP kinase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
GHMP kinase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6691: Mevalonate kinase (AFU_orthologue AFUA_4G07780)

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mevalonate kinase. [EC: 2.7.1.36]
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
  • CTP, GTP and UTP can also act as donors.
 3022 A0A010RSL8 A0A010RSL8 A0A011QV56 A0A011QV56 A0A014NAH7 A0A014NAH7 A0A014NCB5 A0A014NCB5 A0A015L7P9 A0A015L7P9
(3012 more...)
Diphosphomevalonate decarboxylase. [EC: 4.1.1.33]
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).
    		 1994 A0A010QYS5 A0A010QYS5 A0A015LM53 A0A015LM53 A0A016UCG6 A0A016UCG6 A0A017SLT9 A0A017SLT9 A0A022PZU6 A0A022PZU6
    (1984 more...)
    Hydroxymethylglutaryl-CoA reductase. [EC: 1.1.1.88]
    (R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
      		 32 A0A084IK52 A0A084IK52 A0A086DXX3 A0A086DXX3 A0A0H4I452 A0A0H4I452 A0A0K0XX56 A0A0K0XX56 A0A154QJ31 A0A154QJ31
      (22 more...)
      Galactokinase. [EC: 2.7.1.6]
      ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.
      • Part of the Leloir pathway for galactose metabolism.
      • The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-alpha-D-galactosamine.
      		 4 A0A1E7XAE3 A0A1E7XAE3 A0A1M4NC54 A0A1M4NC54
      Cystathionine beta-lyase. [EC: 4.4.1.8]
      L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
      • The enzyme cleaves a carbon-sulfur bond, releasing L-homocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
      • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
      • The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.
      • Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.6.
      		 4 A0A0B7FWR5 A0A0B7FWR5 A0A0L6U6B1 A0A0L6U6B1
      Phosphomevalonate kinase. [EC: 2.7.4.2]
      ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.
        		 4 A0A0F4YJ61 A0A0F4YJ61 A2R3E5 A2R3E5
        3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
        3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
          		 2 A0A0K0EQ95 A0A0K0EQ95
          D-glycero-alpha-D-manno-heptose-7-phosphate kinase. [EC: 2.7.1.168]
          D-glycero-alpha-D-manno-heptose 7-phosphate + ATP = D-glycero-alpha-D- manno-heptose 1,7-bisphosphate + ADP.
          • The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D- manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria.
          • The enzyme is specific for the alpha-anomer.
          		 2 A0A0J5PD49 A0A0J5PD49
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