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CATH Superfamily 3.30.70.270

Reverse transcriptase/Diguanylate cyclase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 50163: Putative diguanylate cyclase AdrA

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diguanylate cyclase. [EC: 2.7.7.65]
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
  • Can be activated by BeF3, a phosphoryl mimic, which results in dimerization.
  • Dimerization is required but is not sufficient for diguanylate- cyclase activity.
  • Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
 194 A0A023YT24 A0A024KRX4 A0A024L680 A0A025CFX5 A0A026RWK1 A0A026V5A8 A0A027TTX5 A0A028AH34 A0A028DMW4 A0A029L1X5
(184 more...)
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