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CATH Superfamily 3.30.70.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39711: Formate dehydrogenase, alpha subunit

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Formate dehydrogenase. [EC: 1.2.1.2]
Formate + NAD(+) = CO(2) + NADH.
  • The enzyme from most aerobic organisms is devoid of redox-active centers but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centers, flavin and a molybdenum center.
  • Together with EC 1.12.1.2, forms a system previously known as formate hydrogenlyase.
 354 A0A023P0C6 A0A058YXG8 A0A063UQB2 A0A069FUZ1 A0A075RBJ7 A0A076W3S6 A0A076W6L2 A0A077UGI6 A0A080UDM2 A0A080UGK1
(344 more...)
Nitrate reductase. [EC: 1.7.99.4]
Nitrite + acceptor = nitrate + reduced acceptor.
  • The Pseudomonas enzyme is a cytochrome, but the enzyme from Micrococcus halodenitrificans is an iron protein containing molybdenum.
  • Reduced benzyl viologen and other dyes bring about the reduction of nitrate.
 6 F0RPH7 F8I7E7 F8IBK7 G8P060 G8TS15 G8TWF6
Hydrogen dehydrogenase. [EC: 1.12.1.2]
H(2) + NAD(+) = H(+) + NADH.
    		 2 B3R0Z4 C3MLV6
    NADH:ubiquinone reductase (H(+)-translocating). [EC: 1.6.5.3]
    NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
    • The complex is present in mitochondria and aerobic bacteria.
    • Breakdown of the complex can release EC 1.6.99.3.
    • In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH.
    		 2 A0A1E3KWQ8 A0A1E3L692