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CATH Superfamily 3.30.70.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39580: Pyruvate:NADP+ oxidoreductase protein, putative

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate synthase. [EC: 1.2.7.1]
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
 7 A0A0E1L260 A0A175LAY6 A0A1L3NM42 A0A1L3NPL9 A0A1L3NRA4 A0A1L7HMW7 A0A1M4M7Z4
Pyruvate dehydrogenase (NADP(+)). [EC: 1.2.1.51]
Pyruvate + CoA + NADP(+) = acetyl-CoA + CO(2) + NADPH.
  • The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly.
  • Inhibited by oxygen.
 3 B6AEJ2 Q94IN5 Q968X7
Aquacobalamin reductase (NADPH). [EC: 1.16.1.5]
2 cob(II)alamin + NADP(+) + 2 H(2)O = 2 aquacob(III)alamin + NADPH.
  • Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.
  • Formerly EC 1.6.99.11.
 1 Q94IN5