The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5693: Guanylate cyclase soluble subunit alpha-3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
3 P19686 (/IDA) Q02108 (/IDA) Q9WVI4 (/IDA)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
3 P19686 (/TAS) P33402 (/TAS) Q02108 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P33402 (/IPI) Q02108 (/IPI) Q9WVI4 (/IPI)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q9ERL9 (/ISO)
Receptor activity GO:0004872
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
1 Q02108 (/TAS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P19686 (/IDA)
Ion binding GO:0043167
Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
1 P19686 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P19686 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9WVI4 (/NAS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cGMP biosynthetic process GO:0030828
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.
3 F8VQK3 (/IMP) Q3TNN8 (/IMP) Q9ERL9 (/IMP)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
2 P19686 (/IDA) Q02108 (/IDA)
Inflammatory response to wounding GO:0090594
The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.
2 A0A0R4IZA1 (/IMP) E7EZW5 (/IMP)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
1 Q9ERL9 (/IMP)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
1 Q9ERL9 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P33402 (/TAS)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
1 P19686 (/IDA)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
1 Q02108 (/TAS)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
1 Q02108 (/TAS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 Q9ERL9 (/IMP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P19686 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P19686 (/IEP)
Response to defense-related host nitric oxide production GO:0052565
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q9ERL9 (/IMP)
Relaxation of vascular smooth muscle GO:0060087
A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
1 Q9ERL9 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q5U330 (/TAS) Q9WVI4 (/TAS)
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
2 P19686 (/IDA) Q02108 (/IDA)
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
2 P19686 (/TAS) Q02108 (/TAS)
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
1 Q9ERL9 (/ISO)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
1 P19686 (/IDA)