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CATH Superfamily 3.30.70.100

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 728: Heme-degrading monooxygenase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Heme oxygenase (biliverdin-producing). [EC: 1.14.14.18]
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
  • This mammalian enzyme participates in the degradation of heme.
  • The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules.
  • The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO.
  • The enzyme requires NAD(P)H and EC 1.6.2.4.
  • Cf. EC 1.14.15.20.
  • Formerly EC 1.14.99.3.
 19 A0A097B2K2 A0A0B8R0M8 A0A0D8X5S2 A0A0E0UU74 A0A0E1R4C2 A0A0E1Y7M7 A0A0F5Z1G9 A0A0H3GA26 A0A1E7E7E2 A0AFT8
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