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CATH Superfamily 3.30.70.100

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10218: Heme oxygenase (staphylobilin-producing)

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Heme oxygenase (staphylobilin-producing). [EC: 1.14.99.48]
(1) Protoheme + 5 reduced acceptor + 4 O(2) = 5-oxo-delta-bilirubin + Fe(2+) + formaldehyde + 5 acceptor + 4 H(2)O. (2) Protoheme + 5 reduced acceptor + 4 O(2) = 15-oxo-beta-bilirubin + Fe(2+) + formaldehyde + 5 acceptor + 4 H(2)O.
  • This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin.
  • The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % 5-oxo-delta- bilirubin, respectively.
 67 A0A069G0H3 A0A0E1V989 A0A0E2MXQ0 A0A0N1EI28 A0A0Q0WZR7 A0A0U1EJJ2 A0A0Y2D2F7 A0A1E8QCS5 A0A1E8RKH4 A0A1E8WSC7
(57 more...)
Heme oxygenase (biliverdin-producing). [EC: 1.14.14.18]
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
  • This mammalian enzyme participates in the degradation of heme.
  • The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules.
  • The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO.
  • The enzyme requires NAD(P)H and EC 1.6.2.4.
  • Cf. EC 1.14.15.20.
  • Formerly EC 1.14.99.3.
 31 A0A0N1EI28 A0A0Y2D2F7 A0A1E8QCS5 A0A1E8RKH4 A0A1E8ZY20 A0A1E9HDF1 A0A1E9IYW5 A0A1E9L5Q0 A0A1E9UAB3 A0A1F0V8M8
(21 more...)
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