The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4574: Serine protease inhibitor Kazal-type 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Peptidase inhibitor activity GO:0030414
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
22 Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP)
(12 more)
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of antibacterial peptide production GO:0002787
Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production.
22 Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP)
(12 more)
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
22 Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP)
(12 more)
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
22 Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP)
(12 more)
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
22 Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP)
(12 more)
Negative regulation of serine-type peptidase activity GO:1902572
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.
22 Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP) Q148R4 (/IMP)
(12 more)
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Hair cell differentiation GO:0035315
The process in which a relatively unspecialized cell acquires specialized features of a hair cell.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Anagen GO:0042640
The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Regulation of T cell differentiation GO:0045580
Any process that modulates the frequency, rate or extent of T cell differentiation.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Cornification GO:0070268
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
24 E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA) E7EWP9 (/IDA)
(14 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Epidermal lamellar body GO:0097209
A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
22 Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO) Q148R4 (/ISO)
(12 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
13 Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS) Q9NQ38 (/NAS)
(3 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
13 Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS) Q9NQ38 (/TAS)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)
Epidermal lamellar body GO:0097209
A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.
13 Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA) Q9NQ38 (/IDA)
(3 more)