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CATH Superfamily 3.30.559.10

Chloramphenicol acetyltransferase-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Chloramphenicol acetyltransferase-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22442: Nonribosomal peptide synthetase 1

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phenylalanine racemase (ATP-hydrolyzing). [EC: 5.1.1.11]
ATP + L-phenylalanine + H(2)O = AMP + diphosphate + D-phenylalanine.
    		 11 A0A0F4Z4X1 A0A0F4Z4X1 A0A0F4Z4X1 A0A0F4Z4X1 A0A0F4Z4X1 B2J684 B8MDW9 B8MDW9 B8MDW9 B8MDW9
    (1 more...)
    Aspartate racemase. [EC: 5.1.1.13]
    L-aspartate = D-aspartate.
    • Also acts, at half the rate, on L-alanine.
    		 8 B8LZU2 B8MDW9 B8MDW9 B8MDW9 B8MDW9 K9VUV8 K9XF76 K9XL33
    Long-chain-fatty-acid--CoA ligase. [EC: 6.2.1.3]
    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
    • Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
    • The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).
    		 7 A0ZL94 S5TLG7 S5TLG7 S5TN15 S5TN15 S5TND9 S5TND9
    Ornithine racemase. [EC: 5.1.1.12]
    L-ornithine = D-ornithine.
      		 5 A5EAZ5 A5EAZ5 B2IXK0 H0RUH5 H0RUH5
      N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase. [EC: 6.3.2.26]
      L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H(2)O = N-(L-5- amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate.
      • The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.
      • Forms part of the penicillin biosynthesis pathway.
      		 5 A0A0F4YTD2 B8M109 B8M4E7 B8MC36 B8MM62
      L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.31]
      (S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
        		 1 B2J684
        D-alanine--poly(phosphoribitol) ligase. [EC: 6.1.1.13]
        ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D- alanyl-poly(ribitol phosphate).
        • A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine prosthetic group of D-alanyl carrier protein during the activation of the alanine.
        • Involved in the synthesis of teichoic acids.
        		 1 A0A0B5P1P3
        Glutamate racemase. [EC: 5.1.1.3]
        L-glutamate = D-glutamate.
          		 1 B2IXK0
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