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CATH Superfamily 3.30.559.10

Chloramphenicol acetyltransferase-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Chloramphenicol acetyltransferase-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22022: 2-oxoglutarate dehydrogenase E1 component

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-oxoglutarate decarboxylase. [EC: 4.1.1.71]
2-oxoglutarate = succinate semialdehyde + CO(2).
  • Highly specific.
 165 A0A049E1F1 A0A059MT34 A0A064CKF1 A0A069JCC8 A0A072Z857 A0A076EH08 A0A083WDI9 A0A098BUI6 A0A099CP09 A0A0A1FVM7
(155 more...)
Oxoglutarate dehydrogenase (succinyl-transferring). [EC: 1.2.4.2]
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
  • It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
 54 A0A083WDI9 A0A098BUI6 A0A0D6IV97 A0A0E4A9A4 A0A0E8NQ10 A0A0H3L8Z0 A0A0K2YGM1 A0A0M3Q9E4 A0A0N9Y545 A0A0U3IHN3
(44 more...)
2-hydroxy-3-oxoadipate synthase. [EC: 2.2.1.5]
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO(2).
  • The product decarboxylates to 5-hydroxy-4-oxopentanoate.
  • The enzyme can decarboxylate 2-oxoglutarate.
  • Acetaldehyde can replace glyoxylate.
  • Formerly EC 4.1.3.15.
 36 A0A083WDI9 A0A098BUI6 A0A0E4A9A4 A0A0E8NQ10 A0A0G4DYC7 A0A0H3L8Z0 A0A0J6VCH4 A0A0J6WEM5 A0A0J6Z9E2 A0A0K2YGM1
(26 more...)
Dihydrolipoyllysine-residue succinyltransferase. [EC: 2.3.1.61]
Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)- (S-succinyldihydrolipoyl)lysine.
  • A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2 and EC 1.8.1.4.
  • The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalyzed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.
 29 A0A083WDI9 A0A098BUI6 A0A0A1FVM7 A0A0E8NQ10 A0A0H3L8Z0 A0A0K2YGM1 A0A0N9Y545 A0A197SE88 A0A1A0U021 A0A1K2TGF4
(19 more...)