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CATH Superfamily 3.30.470.20

ATP-grasp fold, B domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, B domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 31264: FO synthase subunit 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. [EC: 6.3.2.6]
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.
  • Forms part of the purine biosynthesis pathway.
 358 A0A062V2Q1 A0A063ZEB0 A0A068MY57 A0A073CDC5 A0A076GYP8 A0A076H7G3 A0A076HDN1 A0A076LBT0 A0A077JDQ7 A0A081GPI8
(348 more...)
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase. [EC: 2.5.1.77]
5-amino-6-(D-ribitylamino)uracil + 3-(4-hydroxyphenyl)pyruvate + 2 S-adenosyl-L-methionine + H(2)O = 7,8-didemethyl-8-hydroxy-5- deazariboflavin + 2 L-methionine + 2 5'-deoxyadenosine + oxalate + NH(3).
  • The [4Fe-4S] cluster is coordinated by 3 cysteines and an exchangeable AdoMet molecule.
  • The first stage of catalysis is reduction of the 2 AdoMet to produce 2 methionine and 2 5'-deoxyadenosin-5-yl radicals that extract a hydrogen from each of the substrates permitting the condensation of the two.
  • The overall reaction catalyzed is the transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6- ribitylaminopyrimidine-2,4(1H,3H)-dione to form 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO).
  • 7,8-didemethyl-8-hydroxy-5-deazariboflavin is the chromophore of the hydride carrier coenzyme F420.
 1 Q2FQJ2
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