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CATH Superfamily 3.30.465.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17106: Xanthine dehydrogenase FAD-binding subunit

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Xanthine dehydrogenase. [EC: 1.17.1.4]
(1) Xanthine + NAD(+) + H(2)O = urate + NADH. (2) Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH.
  • Acts on a variety of purines and aldehydes, including hypoxanthine.
  • The mammalian enzyme can also convert all-trans retinol to all-trans- retinoate, while the substrate is bound to a retinoid-binding protein.
  • The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum center.
  • The mammallian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4).
  • During purification the enzyme is largely converted to an O(2)- dependent form, EC 1.17.3.2.
  • The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds (which can be catalyzed by EC 1.8.4.7 in the presence of glutathione disulfide) or limited proteolysis, which results in irreversible conversion.
  • The conversion can also occur in vivo.
  • Formerly EC 1.2.1.37 and EC 1.1.1.204.
 217 A0A023Z2R8 A0A024KQ32 A0A025CYE2 A0A026S1T3 A0A026UVK0 A0A027U8C3 A0A028ADL4 A0A028E7D5 A0A029HK33 A0A029IM61
(207 more...)
Nicotinate dehydrogenase. [EC: 1.17.1.5]
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH.
  • The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate.
  • The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.
  • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
  • Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
  • Formerly EC 1.5.1.13.
 101 A0A023Z2R8 A0A025CYE2 A0A026UVK0 A0A027U8C3 A0A028ADL4 A0A028E7D5 A0A029LDQ1 A0A062Y577 A0A069X5V4 A0A070DU69
(91 more...)
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