The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16728: L-galactono-1,4-lactone dehydrogenase, mitochondri...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-galactonolactone dehydrogenase. [EC: 1.3.2.3]
L-galactono-1,4-lactone + 4 ferricytochrome c = L-dehydroascorbate + 4 ferrocytochrome c + 4 H(+).
  • Catalyzes the final step in the biosynthesis of L-ascorbic acid in higher plants and in nearly all higher animals with the exception of primates and some birds.
  • Very specific for its substrate L-galactono-1,4-lactone as D-galactono-gamma-lactone, D-gulono-gamma-lactone, L-gulono-gamma- lactone, D-erythronic-gamma-lactone, D-xylonic-gamma-lactone, L-mannono-gamma-lactone, D-galactonate, D-glucuronate and D-gluconate are not substrates.
  • FAD, NAD(+), NADP(+) and O(2) (cf. EC 1.3.3.12) cannot act as electron acceptor.
21 A0A078GCD4 A0A0B2QUG1 A0A0B2RAX8 A0A0H4LTI6 A0A159BQ96 A0A178VN92 B6ZL96 C0LQA3 C0LVB5 C3S7Q7
(11 more...)
L-gulonolactone oxidase. [EC: 1.1.3.8]
L-gulono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2).
  • The product spontaneously isomerizes to L-ascorbate.
  • While most higher animals can synthesize ascorbic acid, primates and guinea pigs cannot.
2 A0A0B2RAX8 B9SZT2
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