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CATH Superfamily 3.30.460.10

Beta Polymerase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Beta Polymerase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5268: CCA-adding enzyme

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
CCA tRNA nucleotidyltransferase. [EC: 2.7.7.72]
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
  • The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence.
  • The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms.
  • Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition.
  • Formerly EC 2.7.7.21 and EC 2.7.7.25.
 23 A0A0D1JFY6 A0A0K6JQY9 A0A0K6L860 A0A0K6LD58 A0A0K6M3Z1 A0A0T8PXA6 A0A125UJ86 A0A136G3Y1 A0A164XE11 A0A165AFZ2
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