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CATH Superfamily 3.30.460.10

Beta Polymerase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Beta Polymerase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18029: CCA tRNA nucleotidyltransferase, mitochondrial

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
CCA tRNA nucleotidyltransferase. [EC: 2.7.7.72]
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
  • The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence.
  • The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms.
  • Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition.
  • Formerly EC 2.7.7.21 and EC 2.7.7.25.
 12 A6ZRC4 B3LRS8 B5VHU6 C7GS42 G2WD54 P21269 Q8IIG2 Q9P4S5 Q9UTQ0 Q9Y7U9
(2 more...)
Transferred entry: 2.7.7.72. [EC: 2.7.7.25]
    		3 B9T6L0 Q42867 Q9HGK5
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