The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Beta Polymerase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17944: 2'-5' oligoadenylate synthetase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
12 A8DPD5 (/ISS) A8YPE2 (/ISS) A8YPF0 (/ISS) A8YPF4 (/ISS) A8YPF5 (/ISS) A8YPF7 (/ISS) A8YPG1 (/ISS) F7EI59 (/ISS) Q29599 (/ISS) Q5BKD0 (/ISS)
(2 more)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
10 A8DPD5 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC74 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS) Q5MYI7 (/ISS) Q5R8W5 (/ISS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
9 A0A0J9YV76 (/IDA) P00973 (/IDA) P11928 (/IDA) Q05BJ7 (/IDA) Q60856 (/IDA) Q8C2W3 (/IDA) Q8VI95 (/IDA) Q8VI96 (/IDA) Q924S2 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
6 B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) Q5R8W5 (/ISS)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
4 P00973 (/IDA) P11928 (/IDA) Q05961 (/IDA) Q29599 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P00973 (/IPI) P11928 (/IPI) Q60856 (/IPI) Q8VI95 (/IPI)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
3 P11928 (/ISO) Q05BJ7 (/ISO) Q8K469 (/ISO)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
3 P11928 (/ISO) Q05BJ7 (/ISO) Q8K469 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P11928 (/ISO) Q05BJ7 (/ISO) Q8K469 (/ISO)
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
1 Q8VI95 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P00973 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P00973 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
14 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) B6RC74 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS)
(4 more)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
13 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) B6RC74 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS)
(3 more)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
11 A8DPD5 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC74 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS) Q5MYI7 (/ISS) Q5MYW5 (/ISS)
(1 more)
Regulation of ribonuclease activity GO:0060700
Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
10 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) F7I446 (/ISS) Q5R8W5 (/ISS)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
6 B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) Q5R8W5 (/ISS)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
3 P00973 (/IDA) P11928 (/IDA) Q29599 (/IDA)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
3 P00973 (/IDA) Q29599 (/IDA) Q60856 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 P00973 (/IDA) Q60856 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 P11928 (/TAS) Q05961 (/TAS)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 P00973 (/IDA) Q29599 (/IDA)
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
1 Q8VI95 (/IMP)
Ovulation from ovarian follicle GO:0001542
The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.
1 Q8VI95 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 P00973 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 Q5BKD0 (/ISS)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
1 P00973 (/IDA)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P00973 (/IMP)
Negative regulation of viral process GO:0048525
Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant.
1 P11928 (/IDA)
Protein oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P00973 (/IDA)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P00973 (/TAS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P00973 (/TAS)
Regulation of ribonuclease activity GO:0060700
Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
1 P00973 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) B6RC74 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) F6V880 (/ISS) F7EI55 (/ISS) Q5R8W5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P11928 (/ISO) Q05BJ7 (/ISO) Q8K469 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P00973 (/IDA) Q29599 (/IDA) Q8VI95 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P11928 (/ISO) Q05BJ7 (/ISO) Q8K469 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 F8VXY3 (/IDA) H0YI20 (/IDA) P00973 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P11928 (/ISO) Q05BJ7 (/ISO) Q8K469 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P00973 (/IDA) Q05961 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q60856 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q5BKD0 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P00973 (/TAS)
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