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CATH Superfamily 3.30.460.10

Beta Polymerase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Beta Polymerase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17930: CCA-adding enzyme

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
CCA tRNA nucleotidyltransferase. [EC: 2.7.7.72]
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
  • The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence.
  • The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms.
  • Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition.
  • Formerly EC 2.7.7.21 and EC 2.7.7.25.
 3932 A0A011RKT4 A0A011RKT4 A0A022ND83 A0A022ND83 A0A023CKN9 A0A023CKN9 A0A023CUN2 A0A023CUN2 A0A023DFY5 A0A023DFY5
(3922 more...)
Polynucleotide adenylyltransferase. [EC: 2.7.7.19]
ATP + RNA(n) = diphosphate + RNA(n+1).
  • Also acts slowly with CTP.
  • Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group.
  • See also EC 2.7.7.6.
 8 A0A0T9ACZ5 A0A0T9ACZ5 A0A0U0PWK0 A0A0U0PWK0 A0A1M9E5I3 A0A1M9E5I3 I3U152 I3U152
Transferred entry: 2.7.7.72. [EC: 2.7.7.25]
    		4 B0NXS2 B0NXS2 D4MY76 D4MY76
    Transferred entry: 2.7.7.72. [EC: 2.7.7.21]
      		4 B0NXS2 B0NXS2 D4MY76 D4MY76
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