The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 87813: Potassium channel erg1a
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 26 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
8 | B3DJX4 (/IDA) E9QJ94 (/IDA) F6NT38 (/IDA) O08962 (/IDA) O35219 (/IDA) O54852 (/IDA) O54853 (/IDA) Q12809 (/IDA) |
|
Inward rectifier potassium channel activity GO:0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
|
5 | O08962 (/IDA) O35219 (/IDA) O54852 (/IDA) O54853 (/IDA) Q12809 (/IDA) |
|
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
|
4 | B3DJX4 (/IDA) E9QJ94 (/IDA) F6NT38 (/IDA) O08962 (/IDA) |
|
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
|
3 | B3DJX4 (/IMP) E9QJ94 (/IMP) F6NT38 (/IMP) |
|
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
3 | B3DJX4 (/ISS) E9QJ94 (/ISS) F6NT38 (/ISS) |
|
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
2 | O08962 (/IDA) O54852 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | O08962 (/IPI) Q12809 (/IPI) |
|
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
2 | O08962 (/IPI) Q12809 (/IPI) |
|
Inward rectifier potassium channel activity GO:0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
|
1 | O35219 (/ISO) |
|
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | O35219 (/ISO) |
|
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
|
1 | Q12809 (/IDA) |
|
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
|
1 | Q12809 (/IGI) |
|
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
|
1 | O35219 (/ISO) |
|
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
1 | O54853 (/TAS) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q12809 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | O35219 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q12809 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | O35219 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q12809 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O35219 (/ISO) |
|
C3HC4-type RING finger domain binding GO:0055131
Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.
|
1 | Q12809 (/IPI) |
|
C3HC4-type RING finger domain binding GO:0055131
Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.
|
1 | O35219 (/ISO) |
|
Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | Q12809 (/IC) |
|
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
1 | O35219 (/ISO) |
|
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | Q12809 (/IMP) |
|
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | O35219 (/ISO) |
There are 49 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
4 | B3DJX4 (/IMP) E9QJ94 (/IMP) F6NT38 (/IMP) Q12809 (/IMP) |
|
Membrane repolarization during cardiac muscle cell action potential GO:0086013
The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
4 | B3DJX4 (/IMP) E9QJ94 (/IMP) F6NT38 (/IMP) Q12809 (/IMP) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | O08962 (/IDA) O54852 (/IDA) O54853 (/IDA) |
|
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
3 | B3DJX4 (/IMP) E9QJ94 (/IMP) F6NT38 (/IMP) |
|
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
3 | O08962 (/IDA) O35219 (/IDA) Q12809 (/IDA) |
|
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
3 | O08962 (/IDA) O54852 (/IDA) O54853 (/IDA) |
|
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
3 | B3DJX4 (/IMP) E9QJ94 (/IMP) F6NT38 (/IMP) |
|
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
|
2 | O35219 (/IDA) Q12809 (/IDA) |
|
Regulation of heart rate by hormone GO:0003064
The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
|
1 | Q12809 (/TAS) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | O08962 (/IEP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | O54852 (/IEP) |
|
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
|
1 | O08962 (/IEP) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q12809 (/IDA) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | O35219 (/ISO) |
|
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | O35219 (/ISO) |
|
Potassium ion homeostasis GO:0055075
Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.
|
1 | Q12809 (/IDA) |
|
Potassium ion homeostasis GO:0055075
Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.
|
1 | O35219 (/ISO) |
|
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
1 | Q12809 (/IMP) |
|
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
|
1 | O35219 (/ISO) |
|
Regulation of membrane repolarization GO:0060306
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative.
|
1 | Q12809 (/IDA) |
|
Regulation of membrane repolarization GO:0060306
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative.
|
1 | O35219 (/ISO) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
1 | O35219 (/IDA) |
|
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
|
1 | O35219 (/ISO) |
|
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
|
1 | Q12809 (/TAS) |
|
Potassium ion export GO:0071435
The directed movement of potassium ions out of a cell or organelle.
|
1 | Q12809 (/IDA) |
|
Potassium ion export GO:0071435
The directed movement of potassium ions out of a cell or organelle.
|
1 | O35219 (/ISO) |
|
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
|
1 | O35219 (/ISO) |
|
Ventricular cardiac muscle cell action potential GO:0086005
An action potential that occurs in a ventricular cardiac muscle cell.
|
1 | Q12809 (/IMP) |
|
Ventricular cardiac muscle cell action potential GO:0086005
An action potential that occurs in a ventricular cardiac muscle cell.
|
1 | O35219 (/ISO) |
|
Membrane depolarization during action potential GO:0086010
The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
|
1 | Q12809 (/IDA) |
|
Membrane depolarization during action potential GO:0086010
The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
|
1 | O35219 (/ISO) |
|
Membrane repolarization during action potential GO:0086011
The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
1 | Q12809 (/IDA) |
|
Membrane repolarization during action potential GO:0086011
The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
1 | O35219 (/ISO) |
|
Membrane repolarization during cardiac muscle cell action potential GO:0086013
The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
1 | O35219 (/ISO) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | O35219 (/IDA) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | Q12809 (/IMP) |
|
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
|
1 | O35219 (/ISO) |
|
Potassium ion export across plasma membrane GO:0097623
The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
1 | Q12809 (/IGI) |
|
Potassium ion export across plasma membrane GO:0097623
The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
1 | O35219 (/ISO) |
|
Membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915
The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
1 | Q12809 (/IMP) |
|
Membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915
The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
1 | O35219 (/ISO) |
|
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | Q12809 (/IDA) |
|
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | O35219 (/ISO) |
|
Negative regulation of potassium ion transmembrane transport GO:1901380
Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | Q12809 (/IDA) |
|
Negative regulation of potassium ion transmembrane transport GO:1901380
Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | O35219 (/ISO) |
|
Positive regulation of potassium ion transmembrane transport GO:1901381
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | Q12809 (/IDA) |
|
Positive regulation of potassium ion transmembrane transport GO:1901381
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
|
1 | O35219 (/ISO) |
|
Negative regulation of potassium ion export GO:1902303
Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export.
|
1 | Q12809 (/IDA) |
|
Negative regulation of potassium ion export GO:1902303
Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export.
|
1 | O35219 (/ISO) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q12809 (/TAS) Q9H252 (/TAS) Q9NS40 (/TAS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | B3DJX4 (/ISS) E9QJ94 (/ISS) F6NT38 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | O35219 (/IDA) Q12809 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | O08962 (/IDA) O54853 (/IDA) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | O35219 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O35219 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q12809 (/IMP) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O35219 (/ISO) |
|
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
|
1 | Q12809 (/IDA) |
|
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
|
1 | Q12809 (/IMP) |
|
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
|
1 | O35219 (/ISO) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q12809 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | O35219 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q12809 (/IMP) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | O35219 (/ISO) |