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CATH Superfamily 3.30.450.20

PAS domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 56674: Heme-regulated cyclic AMP phosphodiesterase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cyclic-guanylate-specific phosphodiesterase. [EC: 3.1.4.52]
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
  • Inhibited by Ca(2+) and Zn(2+).
  • Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive.
  • It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
 125 A0A017IH96 A0A023YXA1 A0A025CBI1 A0A027ZFV3 A0A028E0W5 A0A029I4G0 A0A029IUG7 A0A029KUL8 A0A029LMT4 A0A029PMA3
(115 more...)
3',5'-cyclic-nucleotide phosphodiesterase. [EC: 3.1.4.17]
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
  • Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
 4 A0A0A2RR66 A0A192C606 A0A1L8ZV20 W8ZS36